UK CLL Forum, UKCLLFORUM

NICE and Fludarabine

Topic Made On: Jan 03, 2008 10:24am
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You may be interested to know that today NICE in the UK (National Institute for Health and Clinical Excellence) published its final judgment on Fludarabine (TA119) as a single agent or in combination.

Summary
Fludarabine given on its own is not recommended as an initial treatment for people with chronic lymphocytic leukaemia (CLL). Fludarabine is not licensed to be prescribed for CLL in combination with other chemotherapy medicines. This is because its ‘marketing authorisation', which is normally needed before a drug can be prescribed, did not cover combination treatment. NICE was therefore unable to look at fludarabine in combination with other chemotherapy drugs for people with CLL. The process of giving a drug its marketing authorisation is not related to the NICE appraisal process and it is not carried out by NICE.

Full details can be found at the following address:

www.nice.org.uk/guidance/TA119

Follow the links for more information.

However, if Fludarabine is important to you, and you feel that it’s your drug of choice, then you may be able to use the following statement that has been lifted from TA119:

This guidance represents the view of the Institute, which was arrived at after careful consideration of the evidence available. Healthcare professionals are expected to take it fully into account when exercising their clinical judgement. The guidance does not, however, override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.




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