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Cardiff University's leukaemia excellence award

Topic Made On: May 19, 2011 09:17am
Nick

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Cardiff University is being named the UK's first Leukaemia and Lymphoma Research centre of excellence.

http://news.bbc.co.uk/1/hi/wales/south_east/8688787.stm

Cardiff is looking at the two most common forms of adult leukaemia - acute myeloid leukaemia (AML) and chronic lymphocytic leukaemia (CLL).

Current research aims to allow doctors to predict who will respond to treatment and how effective drugs are.

The charity has invested more than £1m at the university's school of medicine so far this year and around £6.5m in the last decade.

These programmes are seeking to dissect what's going wrong in the leukaemia cells themselves and this will have two useful consequences for patients.

"One, it can allow us to predict who is going to respond well to currently available treatment.

"Two, it might produce targets which particular drugs might be able to hit."

Over 2,000 adults are diagnosed with AML every year and 3,000 adults with CLL.

Leukaemia & Lymphoma Research currently has six research projects running in Cardiff dedicated to improving diagnosis and treatment for these two types of blood cancer

A new drug for CLL, called LC-1 was recently developed by scientists in their Cardiff laboratories and a clinical trial using the drug will be available soon to patients at the University Hospital of Wales.

Blood cancer patients in Cardiff are set to benefit from clinical trials being "pooled" with a dozen other UK hospitals, says a research charity.

http://www.bbc.co.uk/news/uk-wales-mid-wales-13419103

Leukaemia and Lymphoma Research says the move will give patients with a rare disease better access to trial drugs.

University Hospital of Wales (UHW) has been named as a specialist centre in a network of 13 hospitals across the UK.





Replied On: Nov 16, 2011 03:09pm
Nick

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Being Local to me I had to give them a "big up" There is much going on in the research feild.

An interesting research project commencing at UHW funded by Leukaemia & lymphoma research (again this was an international post showing me what is happening on my own doorstep!!) Thanks Chris of CLL Canada.

Scientists at Cardiff University have been awarded £216,500 by Leukaemia & Lymphoma Research to investigate mutations that cause the development of CLL.

The Cardiff team, headed by Dr Duncan Baird and Dr Chris Pepper, have discovered that testing for damage at the ends of chromosomes (telomeres) in CLL cells is an accurate
predictor of the progression of CLL.

"They have already discovered that 'telomeres', the caps on the end of chromosomes which protect them during cell division, are gradually shortened as the CLL progresses. When the telomeres become completely dysfunctional in the CLL cells, they can fuse together during cell division,
making the cells even more malignant and accelerating the cancer in the blood."

"Dr Baird, of the University's School of Medicine, said, "Using CLL cells and the latest technology which allows us to detect tiny amounts of DNA, we will map exactly the link between chromosome damage and each stage of the cancer. The ultimate goal is to find ways to interfere with the process and develop drugs to actually stop the leukaemia progressing."

http://tinyurl.com/6m2m6mg




Replied On: Dec 04, 2011 03:20pm
Nick

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The Cardiff university post, prompted me to have a look at other new UK research projects awarded funding at Leukaemia and lymphoma research, centres of excellence. There are a few CLL specific, A project researching the MYC protein was interesting.

Southampton scientists research new ways to treat blood cancers. 08 November 2011

http://www.soton.ac.uk/mediacentre/news/2011/nov/11_111.shtml

“If the MYC protein is found to be important in the development of the leukaemia, the Southampton team will test drugs that disable the protein. If they can block the protein from functioning in CLL cells, they may have found a new way of preventing the cancer from progressing in patients.”

“Dr David Grant, Scientific Director at Leukaemia & Lymphoma Research, said: “We are very excited to be funding this work at the University of Southampton. Chronic lymphocytic leukaemia is the most common form of leukaemia diagnosed in adults in the UK, but it remains incurable. Many successful treatments being developed for blood cancers in recent years are designed to slow the progression of the disease and keep it in its early stages. We hope that this research will contribute to this progress.”

“The University of Southampton is a Leukaemia & Lymphoma Research ‘Centre of Excellence’, and the charity is currently investing £6.5 million into vital blood cancer research in the institution.”

Links to centres of excellence: http://leukaemialymphomaresearch.org.uk/our-centres-excellence

“By focusing our investment in Centres of Excellence we are accelerating the delivery of new and better treatments to patients touched by blood cancers, including leukaemia, lymphoma and myeloma.”

New research grants awarded 20th July 2011 http://leukaemialymphomaresearch.org.uk/sites/default/files/New%20grants%20July2011_0.pdf

New research grants awarded March 2011: http://leukaemialymphomaresearch.org.uk/sites/default/files/Grants%20awarded%20March%202011_2.pdf



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