UK CLL Forum, UKCLLFORUM

prognostic markers in untreated CLL patients

Topic Made On: Jan 06, 2012 04:23am
Nick

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Posts: 104
Two recent papers from From the Cardiff research group, UK have been accepted for publication. Both papers involved the study of prognostic markers in untreated CLL patients, and suggest immune or tumour cell markers that correlate with disease progression.

Expansion of a CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.
http://www.ncbi.nlm.nih.gov/pubmed/22190592

“Our data show that the emergence of CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with more aggressive clinical disease. Importantly, these findings were independent of tumor cell prognostic markers and could not be accounted for by patient age, changes in regulatory T cell frequency or cytomegalovirus serostatus.”

Defining the prognosis of early stage chronic lymphocytic leukaemia patients.
http://www.ncbi.nlm.nih.gov/pubmed/22171799

“Approximately 70% of chronic lymphocytic leukaemia (CLL) patients present with early stage disease, therefore defining which patients will progress and require treatment is a major clinical challenge. Here, we present the largest study of prognostic markers ever carried out in Binet stage A patients”

The latter, interpreted, translated and written about by Chaya at CLL topics

“Doc , how long do I have”

http://updates.clltopics.org/4336-doc-how-long-do-i-have

What can newly diagnosed CLL patients expect?

Nick




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