Effectiveness of Reduced Intensity Allogeneic Stem Cell Transplants

Topic Made On: Jan 06, 2008 08:30pm
Robert Cork

Gender: Male
Posts: 160
Effectiveness of Reduced Intensity Allogeneic Stem Cell Transplants for Chronic Lymphocytic Leukemia (CLL) Confirmed.

Researchers from the Fred Hutchinson Cancer Research Center (FHCRC) have presented long-term follow-up data showing that approximately 50% of patients receiving reduced intensity allogeneic stem cell transplants for advanced chronic lymphocytic leukemia (CLL) are alive at five years. This and another study presented at the 2007 meeting of the American Society of Hematology, December 8-11, in Atlanta, Georgia also showed that allogeneic stem cell transplantation was successful in patients with adverse cytogenetics.

Patients with low grade lymphoma, including CLL, have many palliative treatment options, but, ultimately, virtually all patients become refractory to treatment. Allogeneic stem cell transplantation is the most effective method of producing long-term disease-free survival and possible cure of patients with CLL. However, transplant-related mortality is high following conventional myeloablative treatment regimens. Allogeneic stem cell transplants can also be performed using reduced-intensity treatment regimens resulting in a lower treatment-related mortality while relying on a graft-versus tumor effect of the graft for the anti-lymphoma effect. However, there has been concern about the long-term effectiveness of this approach with very little long-term data available.

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